Systemic Lupus Erythematosus: Immunopathogenesis and Novel Therapeutic Targets

Immunopathogenesis of systemic lupus erythematosus

Novel therapeutic approaches in systemic lupus erythematosus.

Systemic lupus erythematosus is a prototypical systemic autoimmune disease, affecting multiple organs and organ-systems, leading to a wide variety of symptoms, serological and clinical features. The pathogenesis of the disease encompasses a complex interplay among various immune-competent cells and inflammatory mediators, which gives ground to target numerous potentially harmful players in this...

Neurobrucellosis in systemic lupus erythematosus

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

t cells as therapeutic targets in systemic lupus erythematosus

| T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus erythematosus (SLE), and seem to be directly involved in the development of related organ pathology. Defects associated with CD8+ and T‐regulatory (TREG) cell function manifest in parallel with the expanded CD3+CD4–CD8– T cell lineage. The cytokine expression pattern is uniquely characterized by decreased ...

The Immunopathogenesis and Immunopathology of Systemic Lupus Erythematosus

P.H. Schur and E.M. Massarotti (eds.), Lupus Erythematosus: Clinical Evaluation and Treatment, DOI 10.1007/978-1-4614-1189-5_2, © Springer Science+Business Media New York 2012 Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by autoantibody production in association with systemic in fl ammatory manifestations that vary in pattern and severity. This disease occ...